I can plus one this. I thought it was the stimulant dosage in the afternoon that was keeping me up all night, but it turns out to be stress! Once that is relieved, things go back to normal.

My doctor suggests I take Vyvanse on the weekends, 7 days a week - I feel like after taking it so long (almost a decade) I don't know who I am anymore off the pills - like I'm a different person almost?

Did your doctor suggest weekend breaks, or is this something you've tried yourself and found works for you?

Every doctor I have had has recommend taking breaks if and when possible. I try to do it myself, and I think it makes a difference. The research on tolerance to medications is not well agreed upon. I am not expert, but I do not see any biological way that the human body would not gain a tolerance to some degree when constantly exposed to an exogenous substance that alters dopamine, GABA, etc..

Nicotine tolerance is real. So is caffeine, cocaine, meth, etc.. I do not see how our medications would be any different.

Thank you for your input :)