Re:Ask HN: What is one thing that has improved your energy t...
by derAndyG on Wednesday November 15, 2023 @12:28AM
(#38273632)
I am aware of this. I am doing my blood test every 3 months where i check TMAO levels too.
I managed to get the levels back to my base line with garlic extract. I think Andrew Huberman mentioned it somewhere.
Also important, I don’t take Alpha GPC every day. Maybe 3 to 4 days a week
"Recently, concerns have been raised about the potential of alpha-GPC to increase the risk of cardiovascular disease (CVD) because it serves as a substrate for the synthesis of trimethylamine-N-oxide (TMAO) in the gut, and TMAO is associated with adverse cardiovascular outcomes in people with CVD and in mechanistic studies.
A 2021 cohort study of more than 12 million participants (at least 50 years old), including 108,877 alpha-GPC users, reported that alpha-GPC use for at least 12 months was associated with an increased risk of stroke over 10 years. Moreover, a 2021 mouse study found that alpha-GPC supplementation promoted atherosclerosis.
However, the currently available evidence is preliminary in nature, so randomized controlled trials and large cohort studies are needed to confirm these findings."
https://examine.com/supplements/alpha-gpc/#what-are-alpha-gp...