Here’s another contender: https://archive.org/details/The.Dollop.Ep15.Ten.Cent.Beer.Ni...
Caution: I have almost crashed a car on more than one occasion from laughing so hard!
And second: that is a WILD story - I was kind of expecting to get to the end with no pay dirt but that was fantastic.
The message then rolls that you shouldn't smoke because your early death will deprive you of important moments like this one.
This PSA made far more of an impression than most do -- for example, it's mentioned on Friends -- and I think about it often as an example of how the same basic argument can be made in weak or strong terms. It may have been too strong for its own good; I once asked a friend for help finding a video of it and the response was "Oh, I know exactly the commercial you're talking about. I won't help you look for it; I hate that commercial and I don't want to see it again."
I never was able to find it.
It's funny how something can be so available and yet inaccessible at the same time.