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Re:Intermittent fasting more effective than calorie restriction by 01100011 on Wednesday November 08, 2023 @11:23AM (#38192655)
Latest I've heard is that it all boils down to calories and that intermittent fasting (time restricted eating or 8/16)makes you lose muscle faster due to low protein during the fasting period.

Better to eat less calories and consume small amounts of protein throughout the day.

https://youtu.be/G3-EW7nWCbU

I tried IF a couple times in my life. First time, coupled with lots of endurance exercise, worked great but I was constantly fighting to retain muscle. Second time I didn't exercise as much but also didn't lose any weight. I did develop extreme post-meal fatigue though, and that has persisted for years since stopping IF.

Re:Intermittent fasting more effective than calorie restriction by stevedt on Wednesday November 08, 2023 @11:59AM (#38193276)
> you lose muscle faster due to low protein during the fasting period

if this is the reason, then wouldn't adjusting your macros to ensure enough protein mitigate this?

Re:Intermittent fasting more effective than calorie restriction by monopoliessuck on Wednesday November 08, 2023 @12:21PM (#38193676)
The body doesn't store protein in any real capacity. Fat is stored in adipose tissue and carbs in glycogen, but protein must be available in the bloodstream when needed for muscle maintenance and synthesis.

Even if you up your dietary protein during the feeding window, if you're fasting for lengthy periods of time where the protein has already been utilized for fuel, then the muscles are starved and catabolic. There's no passive protein depot built into our physiology muscles can pull from.

Re:Intermittent fasting more effective than calorie restriction by joecool1029 on Wednesday November 08, 2023 @01:06PM (#38194384)
Is it possible some of the area it uses protein from is old cells? I'm thinking parts of digestive system, immune system, old cells it scrubs and reclaims some protein from when fasting. Still catabolic but useful catabolic?
Re:Intermittent fasting more effective than calorie restriction by f311a on Wednesday November 08, 2023 @01:26PM (#38194685)
It is called autophagy and happens regularly in our body, but in very small amount. Do experiece greater results, you need prolonged fasting (3-5 days)