I think they're a bit of a blunt instrument, I was put on them for anxiety after contracting a rare and at the time barely studied neurological disorder and it was unspeakably hellish - it was as though I'd died and my body hadn't caught up yet. I'd find myself doing weird things like pouring half a bottle of hot sauce on my wraps just to feel something. On the other hand I knew someone on an identical dose of an identical SSRI and it basically cured their depression and was a huge benefit.

This year it's been discovered that 5HT2A (ie the sub-type psychedelics target) receptors are implicated in my disorder which would explain why messing around with serotonin-modifying chemicals had adverse effects. I wonder how many people are walking around with sub-clinical neurological issues that get suddenly exacerbated by antidepressants?