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A comment on 'Remarkable' medical discovery for sepsis moves to next phase of human trials. Parent comment

Re:'Remarkable' medical discovery for sepsis moves to next p... by tea-coffee on Friday October 13, 2023 @06:19PM (#37876241)
Would they need to have 2 placebo arms to make this an optimal study design then? One for glucose (as sodium ascorbate was diluted using a glucose solution), and another placebo group for sodium chloride?
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Re:'Remarkable' medical discovery for sepsis moves to next p... by carbocation on Friday October 13, 2023 @08:07PM (#37876924)
Honestly if they had balanced the sodium via almost any mechanism, I wouldn't have had much to say about it. The difficulty with 2 placebo arms is that you have to expand your study population which I think poses an ethical issue, but otherwise yes.
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