> Memetic reproduction need not coincide with biological reproduction.

For a couple generations, maybe. But if the meme is extremely detrimental to the evolutionary fitness of its hosts, eventually adaptations conferring resistance to the meme will become common. Like how sickle cell is more prominent in places where malaria is common, because it confers resistance.

> if the meme is extremely detrimental to the evolutionary fitness of its hosts

This phrase is doing so much work, the rest of your comment was able to retire in the Bahamas. Sounds a lot like the argument that gay people don't exist because they don't reproduce.

Sexual behavior was traditionally constrained by the requirements of survival—you needed a certain number of children to help till the fields and avoid starvation, so people subordinated personal desires to necessity. Today the risk of death is removed, so people do what they want—and "what they want" is therefore subject to greater selective pressure.

Your picture of the human condition predates the agricultural revolution. That doesn't mesh with your idea that evolution happens in the blink of a couple generations.