so does obesity have bad side effects. we need more answers. GLP -1 is a good start

In my opinion orlistat (blocks fat absorption) isn't that bad if you actually follow the suggested low-fat diet. But if you're hoping to counteract a pint of ice cream, it's going to work tooooo well. The Public Relations was a nightmare... never stood a chance. The jokes were too good.

Acarbose blocks starch (and sucrose, to some extent) absorption. Instead of oily poop you get gas that hopefully goes down over time. Starch & sucrose is not as big a part of American caloric intake as fat, but it can still help a bit.

(Just sucrose. HFCS has glucose and fructose, which means sucrase doesn't need to work. Not a meaningful difference in most people considering how fast sucrase works, but when you block sucrase...)