Vaccine Reverse Multiple Sclerosis, Type 1 Diabetes, and Crohn’s

Re:Vaccine Reverse Multiple Sclerosis, Type 1 Diabetes, and ... by kieranmaine on Thursday September 14, 2023 @01:08PM (#37511695)

The referenced study https://www.nature.com/articles/s41551-023-01086-2 says "a mouse model" and "non-human primates":

"We show that pGal–antigen therapy induces antigen-specific tolerance in a mouse model...as well as the suppression of antigen-specific responses to vaccination against a DNA-based simian immunodeficiency virus in non-human primates"

The article also mentions that phase I trials have been carried out with humans:

"initial phase I safety trials have already been carried out in people with celiac disease...and phase I safety trials are underway in multiple sclerosis"

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Re:Vaccine Reverse Multiple Sclerosis, Type 1 Diabetes, and ... by olliej on Thursday September 14, 2023 @02:06PM (#37512556)

Thanks! I didn't think to search for "phase" despite that being an obvious term when wondering about trials.

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Re:Vaccine Reverse Multiple Sclerosis, Type 1 Diabetes, and ... by kamokujin on Friday September 15, 2023 @04:14AM (#37520010)

As someone with Crohn's and Ankylosing Spondylitis, that phase 1 trials had me excited in a long time. I did not take TNF blockers because of the cost and side effects.

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