1. Filtering all resources accesses, letting some pass and others denied.
2. Enforcing different abstraction and then unwanted resources accesses become impossible as they are not even addressable.
Filtering is by definition less secure. As filtering get more complicated there would be false negatives and false positives. Both are harmful.
Enforcing different abstraction is usually less efficient as there is a need to simulate hardware devices. However, some devices have hardware support for virtualization as with Intel CPUs and MR-IOV devices and then enforcing abstraction is free.
LXC/OpenVZ uses mostly #1
XEN/KVM uses mostly #2
1. Small surface for attack. With NaCl it is all concentrated in single tiny validator module. The model is also simple and mathematically proven to be secure. 2. Prior testing. It is especially hard for security product. Establishing motivating prizes is good way to ensure it is not easily breakable. 3. The speed with which patch is made available 4. Defense-in-depth, ability to have multiple levels of defense cheaply.