I've used Catalyst in the past, now at work I am stuck with CGI::Application and it seems rather OK, but still a little step back. At least in Catalyst it is natural to have multiple classes (each for one controller) - while the app being developed here ended up as one huge application class.

But really the more imporatant part of the decision is what templating and ORM to use. I have a blog post on that: http://perlalchemy.blogspot.com/2008/10/progress.html .