Re:A DIY ‘bionic pancreas’ is changing diabetes care – what'...
by awaywethrow on Wednesday August 30, 2023 @05:58PM
(#37329699)
To clarify, the context of this thread / what I was originally responding to was:
> In this case, you could be more aggressive in either direction of pushing BG, because you have a safety net.
Bihormonal pumps do not mean continuous infusions of both insulin and glucagon. The pumps pulse insulin when you're high and glucagon when you're low. They're not both administered at the same time or continuously infused in a "balanced state".
The context in this thread:
> However, if your brakes (glucagon) can sometimes fail completely
A bihormonal system would not result in more insulin being administered than an insulin-only system for a given blood sugar, if the glucagon pump fails we would have an insulin-only system where we have plenty of safety data. There is no mechanism by which a bihormonal system has higher risk of hypoglycemia than existing closed loop insulin system.