Re:The human Y chromosome has been completely sequenced
by delecti on Friday August 25, 2023 @09:21AM
(#37261405)
I don't think this was a secret. I remember reading an article (IIRC in Readers Digest) nearly ~20 years ago which specifically referred to it as a "shotgun method". I wasn't (and still am not) enough of an expert to have known that was a less authentic/accurate method, but at least at the time the tone was not that they were doing anything illicit.
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Re:The human Y chromosome has been completely sequenced
by throwawaymaths on Saturday August 26, 2023 @03:42PM
(#37276142)
if you go over the maths on the shotgun method, not taking into account systematic difficulty in sequencing (like tandem repeats), the likelihood of incomplete coverage vanishes much more rapidly than you'd expect, and after about 5-10x coverage volume, coverage is basically linear in the total amount of sequencing.