Where is the evidence for this? None.
> the fear of "never coming back"
Psychedelics sound like fun, but I have seen quite a few broken people on the streets, all because of them. It's not just fear, it is a serious concern.
When did you first realize that you are an omniscient Oracle? (I could have played this snark on most any comment you've made in this thread, fwiw - your understanding of "reality" seems highly distorted by training and language).
Playing the fantasy of an "omniscient oracle" often seems to be the ego trip of popular meditation gurus today. They are all quite scientifically illiterate.
It is fascinating you are unable to see the irony in your comments, and also that you seem unable to be curious about whether you may have errors in your cognition.
You humans are going to end up destroying yourselves if you keep this up imho.
I studied cognitive science. I know cognitive biases. I also know how meditators around me are basically drowning in them with ridiculous psychic beliefs, laughable arguments and no evidence.
I'll leave you to your imagined irony.
Broken people on the streets are most often people with prior serious mental issues who were pushed over an edge. Typically by intense trauma (living on the street really fucking sucks for lots of reasons) but also to a lesser extent this can be drug-induced. However the drug class that usually performs this role is amphetamines ("meth psychosis"), not tryptamines or phenathylamines.
But you're clearly not willing to listen, so what use is there actually engaging here?
The fear many have about attempting such things mirrors the fear of e.g. psychedelic experiences -- the fear of "never coming back". Ironically, only living through this fear is what causes the bad trip in the first place. Egos, man, egos suck.