I've witnessed quite a few bad trips and the failure mode corresponds well to my mental model of "ego struggles against ego death so hard the person is driven to psychosis".

Broken people on the streets are most often people with prior serious mental issues who were pushed over an edge. Typically by intense trauma (living on the street really fucking sucks for lots of reasons) but also to a lesser extent this can be drug-induced. However the drug class that usually performs this role is amphetamines ("meth psychosis"), not tryptamines or phenathylamines.

But you're clearly not willing to listen, so what use is there actually engaging here?