I believe he suffered from an illness, but in general I suppose having a full-contact punching and kicking bouts with gigantic men isn't very good for your long-term health anyway. Especially in Kyokushin where they have (had?) no weight classes.
I actually don't think it is the direct damage from fighting that gets them but more the inability to stop and scale your commitment to what you can and can no longer do.
In Isshinryu, there's none of that. You stop the punch/kick before the joint goes to lock. The stances are much shallower. The movements are less dramatic. My sensei told me it is much more sustainable this way, and many of the old taekwondo folks end up with joint issues specifically in knees and elbows. I don't know if it's related, but my knees and elbows are the two parts of my body which are most problematic.
It's also possible my taekwondo instructor just didn't know about this, that was a long time ago.
Performance enhancing drugs
Now I believe that a lot of physical training isn't that healthy. And if you put your whole personal identity on your physical abilities then when your abilities start to decline, as they naturally do from age 40 and up, you may spiral out of control and literally die.