For sure there are differences in the enemy if you consider us already at war with China and/or Russia. It's my personal opinion that WWIII kicked off the day Russia's navy left port and circled around Europe to get to the Mediterranean (Dec 2021), but we haven't technically declared war yet.

Its worth noting that Afghanistan may be less developed technologically but they have now successfully fended off invasions from both the Soviet Union and the US. Never underestimate your enemy in war, especially if you're Goliath invading David's home.