However, I wonder why the pen calibration data is not stored on an controller on the display panel? That would absolutely make sense.
Pencil also has a small calibration table and when paired with a new iPad it checks and downloads that immediately.
If not, it might also be (more likely) sending whatever it senses to iPad and iPad processes that raw input with the calibration data to determine the final output.
Printer manufacturers have been pulling the same trick with storing (approximations of) ink levels in chips in the cartridge, claiming that it makes it easy for users to swap cartridges and continue to have accurate quantities and in that case there's a little bit more truth to the argument, but not this one.
I mean, if cartgridges' calibration drift a bit it might also be more acceptable for many, but if Pencil starts drawing incorrectly many artists would be extremely frustrated and move away from the ecosystem.
At software level iOS registers some calibration data (after some factory calibration) tied to that specific serial number (as calibration makes sense only for that specific instance of the panel anyway) so when serial number changes iOS can't find calibration data on device and continues uncalibrated instead of trying to use calibrations for another-serial screen (from the OS perspective).
It makes sense, if there actually is some sort of calibration going on in the first place of course.