Still lots of complexity and awkwardness that can be avoided if you can do threading instead of processes. Like Promotheus scraping from a non-webserver python app is a pita, as you need a new process and lots of communication, vs just plug and play as in other languages.
Or just the insane resource usage. Had a java app serving multiple orders of magnitude more customers running on a few containers. Our current python app needs multiple deployments with different entry points, and about 15x the amount of containers.
That policy is over.
As the last years have shown, no alternative implementation can get off the ground due to C extensions and compatibility concerns, and CPython is now relied on for many large applications. It no longer makes sense to prioritise a simple implementation over performance.