I made a very serious attempt at using this awhile back on Arch and it high-key sucks. Like, it's not really meant as a general purpose container runtime solution, it's meant for developing systemd and related software. The ergonomics, particularly around networking are quite bad and it literally requires that you're all in on systemd-networkd and resolved to get any networking at all.

I’ve used it as a general purpose container runtime and been very pleased. Ymmv.