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A comment on The Rise and Fall of Evidence Based Medicine (1998) [pdf]. Parent comment

Re:The Rise and Fall of Evidence Based Medicine (1998) [pdf] by LorenPechtel on Friday June 02, 2023 @12:22PM (#36167166)
No, I specifically was referring to fat women. Check the recommendations on birth control pills--same thing, older + fat makes them risky. The problem with the big study is that their sample was disproportionately overweight.
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Re:The Rise and Fall of Evidence Based Medicine (1998) [pdf] by haldujai on Saturday June 03, 2023 @06:15AM (#36175304)
Unopposed estrogen (i.e. the old estrogen only HRT) is bad for women of all sizes, endometrial cancer sucks.

Separately, obesity causes higher system estrogen levels and carries the same risks.

What you may be referring to is the more recent WHI study which does have methodological flaws, but unopposed estrogen is a no-no for patients with a uterus.

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