I would extend that and say all humans don’t do anything significant with their lives. It seems rather likely that humanity as a whole has had zero impact on an overwhelming majority of all life that exists or will exist, intelligent or otherwise.

Granted nobody particularly cares about the absolute scale but if you’re complaining about significance it’s obviously just personal bias.

Alternately, there is only life on this planet, and were going to be responsible for killing it all. You can’t be sure either way, so we must be way way more careful, in case this is it for the universe.