Outside the body is one thing. The EU banned it as a food additive last year and some US states are considering it too. TiO2 has genotoxic traits, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323234/

I always found it odd that my acrylic paint and my toothpaste share this ingredient.

Dihydrogen monoxide too!

Water isn't genotoxic. Titanium is. It's fair to be concerned about chemicals when the chemicals cause objective harm.

Correcting myself, I was thinking of Zinc Oxide. But it's still pretty inert. I wouldn't want a plate of it, but whatever level of toxicity it possesses, it is low enough that it requires careful study to detect.