Aside from the legality, what’s different between a liquor store owner and a weed dealer? You may disagree with their breaking the law, but commerce is commerce, and this is victimless except with regard to the rule of law.

Alcohol serves purposes other than intoxication. A fine wine is terrible thing to drink for inebriation; good vodka is cheaper with fewer side effects.

That being said consumption of alcohol and drugs are not victimless. The beated wife, the ignored children. Sons growing up with father figure with no drive to self improvement. Therefore, I wouldn't mind rolling back a lot of the alcohol liberalization of the past few decades.

There are other ways to handle abuse and addiction besides trying to prohibit a widely-desired substance. You rightfully point out that some people have huge problems with alcohol. The solution isn't just to blanket make it illegal (with the ensuing chaos that would/did cause), but rather directly address the acute harm caused by the people with the problems.

Ultimately the reason we consider some things natural rights isn't to create some prescriptive model for the shape of an enlightened society. Rather it's due to the inevitable ugliness when the government attempts to legislate into individual autonomy, and people react en masse. And the results of the "drug war" have most certainly been quite ugly!