Came here to say this. It’s definitely a bad idea given that so much first stage screening is automated these days. If your CV parses badly you’re just as likely to be silently binned by an algorithm. I say this from personal experience, and now having begrudgingly rolled my CV back from LaTeX to Word.

On my recent job search, I basically only got responses from smaller companies, and I'm now suspicious that this was the reason.

But regardless of whether you wrote your resume in word or LaTeX, 99% of the time you'd send it as a PDF, correct? So are you saying LaTeX pdfs will parse worse than Word PDF's in automatic systems?

In my experience, yes.

What I am saying is when I last ran this experiment a few years back word .doc formatted files (didn’t check .docx) returned the most calls from recruiters in comparison to .txt or .pdf or .html.