News for hackers. Stuff that matters.

A comment on Rapamycin: The unlucky history of the most powerful anti-aging drug. Parent comment

Re:Rapamycin: The unlucky history of the most powerful anti-... by tysam_and on Monday May 08, 2023 @03:43AM (#35859092)
I really appreciate this comment a lot. Feels like it hits the nail on the head.

I've seen some of the discussion about/around the Yamanaka factors and it feels like an anime plot point, honestly. I need to look more into them and understand them a bit better. They're the ones implicated in stem cells returning back to pluripotency, right (and then the long deep dive about DNA damage/repair/what the heck is happening in the disparity between repairing damage for reproduction vs the everyday repair, etc...)?

[ Parent | on HN ]
Re:Rapamycin: The unlucky history of the most powerful anti-... by xiphias2 on Monday May 08, 2023 @03:52AM (#35859125)
You're half right, they are only resetting epigenetics (for example DNA methylation that is important in cell specialization), not DNA.

Altos Labs being funded is both a blessing and a curse, because it funded the best researchers in this area with hundreds of millions of dollars (5-10x their salary in what they were making as university professors), but since it was founded, there are much less publications available.

[ Parent | on HN ]