Re:Longevity Study Across 5 Species Found a New Pathway to R...
by SanderNL on Sunday April 23, 2023 @03:27PM
(#35679633)
My plebeian mind finds it interesting the process quality itself is still the same, only the speed changes. This changes the problem from “change fundamental quality of the process” to “change the speed of the process”, which, again to my unwashed and illiterate eyes, seems like an useful and possibly exciting distinction.
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Re:Longevity Study Across 5 Species Found a New Pathway to R...
by GenerocUsername on Sunday April 23, 2023 @03:33PM
(#35679687)
But it might not be that simple. Perhaps it's 'faster' because it's doing less error checking.
Re:Longevity Study Across 5 Species Found a New Pathway to R...
by derefr on Sunday April 23, 2023 @05:20PM
(#35680746)
My understanding of how the development of cancer works is that all the error-checking mechanisms in a cell have to become damaged, before a cell can be damaged in such a way that it mutates into a cancer cell, because if they aren't all damaged before that, then one of them will find the "error" going on, and self-destruct the cell.
Cancer itself, then, is a constructive proof that DNA damage can disable DNA-transcription-time error-checking mechanisms.
The question in my mind, then, is whether those safety mechanisms are "blocking" / "synchronous" steps done during DNA transcription, such that disabling them would make DNA transcription occur faster. If they are, that would neatly explain the observed effect.