Re:Longevity Study Across 5 Species Found a New Pathway to R...
by derefr on Sunday April 23, 2023 @05:20PM
(#35680746)
My understanding of how the development of cancer works is that all the error-checking mechanisms in a cell have to become damaged, before a cell can be damaged in such a way that it mutates into a cancer cell, because if they aren't all damaged before that, then one of them will find the "error" going on, and self-destruct the cell.
Cancer itself, then, is a constructive proof that DNA damage can disable DNA-transcription-time error-checking mechanisms.
The question in my mind, then, is whether those safety mechanisms are "blocking" / "synchronous" steps done during DNA transcription, such that disabling them would make DNA transcription occur faster. If they are, that would neatly explain the observed effect.
Cancer itself, then, is a constructive proof that DNA damage can disable DNA-transcription-time error-checking mechanisms.
The question in my mind, then, is whether those safety mechanisms are "blocking" / "synchronous" steps done during DNA transcription, such that disabling them would make DNA transcription occur faster. If they are, that would neatly explain the observed effect.