High resources * high demands is probably only the dream of single young newgrads or people without family or other such obligations and want to focus on climbing the ladder and "making it" in the industry.

The people I know who wish to focus their life around their hobbies or kids want to stay away from high demand jobs even if they were to have high resources.

I guess it depends on what "high" and "low" mean. With "high demand" I presumed busy, but assuming there are enough resources, no need to work evenings or weekends.

Low demand doesn't have to mean low purpose. I would split demand out into two: urgency and significance. I want significant work, but not urgent work. Constant urgency will burn me out. Some people may prefer urgent work over non-urgent work because they enjoy the hustle. But I think everyone has limited capacity for urgency.