I love navigating around Seattle so much. The grid does take a few jumps, NE 85th St in Seattle doesn't exactly line up with NE 85th St in Kirkland, (travelling straight across the lake, NE 70th St in Seattle lines up with NE 85th St in Kirkland), but in general if given an address (the first 2 or 3 digits of a house's number indicate cross street) you can navigate to almost anyplace in King County with just a compass.
FWIW there are neighborhoods that are E. The CD, Madison Valley, basically everything south of 520 until Yesler.
You also didn't mention that part of the city grid is on a 45 degree slant due to the city founders not being able to agree which grid system to use. :)
One other aspect I find fascinating about Seattle's system is that there's some redundancy built into the address specification: whether the street is oriented north-south or east-west is not only indicated by whether it's an Ave (N-S) or a Street (E-W), but whether the grid qualifier is specified as a prefix or a suffix. So when you find a partial address on some album art [2], for example, you can deduce that "4718 38NE" is talking about 4718 38th Ave NE and not 4718 NE 38th St.
[1] theoretically nine grids, anyway. As an example, I'm not sure if there's actually an "E" grid. The central grid goes all the way to the water on the east, and when continued on the other side of the lake in Bellevue, the NE and SE grids touch each other.
[2] https://musicbrainz.org/release/36fab830-fc17-48d7-9d7e-194f...