My issue with these browsers, including Firefox with things like fingerprint resisting enabled, is that it breaks a lot of sites. Add a VPN to the mix and a lot of sites flat out refuse to let you interact with them, or they give you 5 minutes of captchas, or they require 2 factor login despite asking them to remember your device. I have to open some sites (banking, brokerage, health insurance) on a near-daily basis in Chrome with no extensions and no VPN instead of my regular firefox+vpn.

A lot of sites allow interaction even with the above but they shadowban you without telling you. Craigslist shadow bans and auto-spam-filters any submissions done with a VPN, and then also auto-spam-filters any subsequent submissions on the same account even with the VPN turned off.

Reddit also universally spam-filters any submissions and comments done under a VPN, and rate limits your commenting a shitload on VPNs.