No, it is not. For example, you can have an application that is doing a lot of memory accesses, but the working set is controlled to fit the cache except for couple of things that need to be fetched into the cache but you make sure those things fit predictable pattern that the CPU prefetcher can recognise and supply in advance of you needing it.

Now, having less memory accesses usually helps, but it is kinda newb way of looking at the problem. What if you have to make a lot of accesses because your application is memory heavy (say it is a database)? Does it mean there is nothing you can do to improve it? Of course there are things you can do to improve it -- but you need a bit more in depth knowledge.