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A comment on Scientists discover why aspirin works so well. Parent comment

Re:Scientists discover why aspirin works so well by paulpauper on Wednesday March 29, 2023 @06:18AM (#35355051)
Yeah, for all the hype about opioids being bad, these 'safe' drugs are way more dangerous than commonly purported. Acetaminophen is especially bad because the overdose threshold is only slightly above the effective dose. That is why they have to put so many warnings on this 'safe' drug. Yet let's blame opioids.
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Re:Scientists discover why aspirin works so well by taneq on Wednesday March 29, 2023 @06:54AM (#35355318)
10:1 is still a pretty big ratio. You could take 20 Panadol every few hours before getting sick. That’s a LOT.
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Re:Scientists discover why aspirin works so well by paulpauper on Wednesday March 29, 2023 @06:57AM (#35355347)
not really. you will be quite sick before you hit 10. also, double dosing is a major problem and makes it easier to hit the threshold .
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Re:Scientists discover why aspirin works so well by taneq on Wednesday March 29, 2023 @08:09PM (#35365838)
Is the definition of “toxicity ratio” not “ratio of therapeutic dose to the amount required for toxic effects”?
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Re:Scientists discover why aspirin works so well by TeaBrain on Wednesday March 29, 2023 @09:37AM (#35357096)
Acetaminophen is simply an analgesic. It isn't considered to be an nsaid.
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Re:Scientists discover why aspirin works so well by rootusrootus on Wednesday March 29, 2023 @11:55AM (#35359043)
Acetaminophen has become a target lately, but the numbers don't really support that level of worry. Relatively few people are injured by acetaminophen overdose, and a large fraction of those are intentional suicide attempts. It's not even close to being the most dangerous OTC drug, ibuprofen kills way more people.
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