You know you can call import functions and call libraries in other languages than python? If everyone was programming in assembly then there would be plenty of libraries to make database calls or make web servers in assembly, and there would be plenty of tutorials online that you could copy and paste to get things going, meaning it wouldn't take much work at all. It would be more work, but not orders of magnitude more work.
If an inefficiency saves a developer 10 days of work, but results in an operation taking 100 milliseconds longer, and you have 50M customers who do that operation just one time, then you've wasted ~58 customer-days.
It makes more sense to tune libraries excessively, we could say it is less of a trade off, more of an allocation of the finite low-level tuning developer resources to high-impact libraries.
Anyway it turns out that the only way to get most people to link to a good BLAS is to use Numpy and distribute it through some giant Anaconda Rube Goldberg machine, so, I dunno, people are weird.
It's some kind of philosophical question.
Maintaining an assembly version of a modern software stack is not 5x more costly, it's simply not possible.
Developer time reduced by 5X CPU time increased by 500x
When CPU cycles are cheap it's a logical tradeoff but it still grates against my sensibilities.