Re:An Update on Dianna's Health (Physics Girl) [video]
by fnordpiglet on Friday March 10, 2023 @12:54AM
(#35090901)
At the risk of being labeled a quack, try taking an L-citrulline supplement of about 1g/10kg of weight. This greatly helped my long COVID recovery.
My thesis, which I have no direct science to back up, is that the blood vessel damage done by COVID may be partially responsible. Citrulline metabolizes in the liver into arginine, which is used in either to produce ATP or by epithelial cells to repair vascular damage. The body prioritizes vascular repair, so the arginine you normally produce if you have vascular damage is directed away from “energy” leaving you chronically fatigued. This is the same process by which sickle cell anemia leads to chronic fatigue - the shape of the sickle cell irritates the blood vessel lining. Citrulline is effective in phase II/III trials (sadly the primary researcher died and the research stopped) with sickle cell patients.
This helped me a great deal, within a few hours of my first consumption of a citrulline malate blend I bought on Amazon I was myself again after a year of suffering. Within a few months I was able to stop supplementing and felt generally normal. YMMV.
I asked several doctors before starting the regime about safety concerns and they had none (the body urinates any excess it can’t process, and citrulline is a non essential amino acid fundamental to the nitric oxide cycle) and they generally expected it would improve energy - as it did.
My thesis, which I have no direct science to back up, is that the blood vessel damage done by COVID may be partially responsible. Citrulline metabolizes in the liver into arginine, which is used in either to produce ATP or by epithelial cells to repair vascular damage. The body prioritizes vascular repair, so the arginine you normally produce if you have vascular damage is directed away from “energy” leaving you chronically fatigued. This is the same process by which sickle cell anemia leads to chronic fatigue - the shape of the sickle cell irritates the blood vessel lining. Citrulline is effective in phase II/III trials (sadly the primary researcher died and the research stopped) with sickle cell patients.
https://pubmed.ncbi.nlm.nih.gov/11688916/
This helped me a great deal, within a few hours of my first consumption of a citrulline malate blend I bought on Amazon I was myself again after a year of suffering. Within a few months I was able to stop supplementing and felt generally normal. YMMV.
I asked several doctors before starting the regime about safety concerns and they had none (the body urinates any excess it can’t process, and citrulline is a non essential amino acid fundamental to the nitric oxide cycle) and they generally expected it would improve energy - as it did.
Good luck!