Poor Sleep Drove Me Insane, and My Long Path to Recovery

Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by thisismyswamp on Monday February 27, 2023 @09:16AM (#34956624)

Can't you drink one coffee in the morning?

Also would like a source on the 2X cardiac event risk, couldn't find that in the linked article. Big if true!

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Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by rednerrus on Monday February 27, 2023 @09:57AM (#34957139)

I have this genotype and if I have a mouthful of coffee at 8 am, I will be able to feel it at 1 AM the following morning.

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Re:Poor Sleep Drove Me Insane, and My Long Path to Recovery by Acutulus on Monday February 27, 2023 @10:27AM (#34957476)

The enzyme responsible is CYP1A2 if I understand correctly. Here is the paper I found that supports increased risk of a specific cardiac event to slow metabolizers. I'm not the most adept at reading medical papers so I can't verify if it claims the risk is doubled, but I think it's possible.

https://jamanetwork.com/journals/jama/fullarticle/202502

Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction Marilyn C. Cornelis, BSc; Ahmed El-Sohemy, PhD; Edmond K. Kabagambe, PhD; et al Hannia Campos, PhD JAMA. 2006;295(10):1135-1141. doi:10.1001/jama.295.10.1135

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