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Re:Bovine meat and milk factor proteine in mucosa of colorec... by tptacek on Sunday February 26, 2023 @01:19PM (#34947850)
Does this square epidemiologically with beef consumption? The countries with the highest beef consumption are in South America (and it's sharply more beef consumption); the countries with the highest colon cancer rates are in central and northern Europe.

It doesn't follow from a correlation that beef is by itself causative; it can be, for instance, beef plus some other X-factor. Somebody is going to point out that South American cattle are grass fed, but European cattle are also more grass fed than American cattle, and yet they still top the leaderboard.

Re:Bovine meat and milk factor proteine in mucosa of colorec... by toomuchtodo on Sunday February 26, 2023 @01:28PM (#34947947)
Heavy use of antibiotics?

Edit: perhaps not

> It is estimated that livestock alone uses 50-80% of the total antibiotics produced in most of the developed countries. China, Brazil, and the United States are the largest consumers of antimicrobials in livestock production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896880/ (Antimicrobial uses for livestock production in developing countries)

Re:Bovine meat and milk factor proteine in mucosa of colorec... by curiousgal on Sunday February 26, 2023 @01:38PM (#34948052)
Beef without fibre?
Re:Bovine meat and milk factor proteine in mucosa of colorec... by code_duck on Sunday February 26, 2023 @02:04PM (#34948311)
Lack of fiber is already a known factor in colorectal cancer, isn't it?
Re:Bovine meat and milk factor proteine in mucosa of colorec... by steponlego on Sunday February 26, 2023 @08:22PM (#34951842)
Is it? I heard that was pop science.
Re:Bovine meat and milk factor proteine in mucosa of colorec... by Alcor on Monday February 27, 2023 @12:10PM (#34958998)
No that's poop science! On a serious note though, seems still undecided but leaning more heavily towards no protective effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357054/

Re:Bovine meat and milk factor proteine in mucosa of colorec... by cma on Sunday February 26, 2023 @01:56PM (#34948242)
Less other causes of death might mean more colorectal cancer as you age. Also age distribution is different (skews way younger in South America for not just longevity reasons) so you need to adjust for that.
Re:Bovine meat and milk factor proteine in mucosa of colorec... by bitL on Sunday February 26, 2023 @02:08PM (#34948355)
Could there be a significant difference in soil composition between South America and Europe, leading to different health outcomes? If you travel through Europe and South America at similar +/- latitudes, the countryside is completely different. Similarly US vs Europe at the same latitude.
Re:Bovine meat and milk factor proteine in mucosa of colorec... by Stealthisbook on Sunday February 26, 2023 @03:20PM (#34948960)
It would be helpful to look at import/export flows. I suspect that quite a large percentage of European beef consumption isn't locally sourced, with likely quite a bit coming from S. America.
Re:Bovine meat and milk factor proteine in mucosa of colorec... by pkaye on Sunday February 26, 2023 @05:15PM (#34950137)
If you know specific countries or trade blocs, you can look it up here.

https://oec.world/en/profile/international_organization/euro...

Re:Bovine meat and milk factor proteine in mucosa of colorec... by davrosthedalek on Sunday February 26, 2023 @04:02PM (#34949426)
Are these numbers corrected for testing bias?
Re:Bovine meat and milk factor proteine in mucosa of colorec... by tpoacher on Tuesday February 28, 2023 @07:23AM (#34968493)
Well, the study was not an RCT, so the authors by necessity argue for the presence of an association, but are technically not claiming a casual relationship (even if the wording does a heavy 'wink wink' at the reader). That, and apparently the findings were not statistically significant.

However, even if there is an association, and it is "causal", given this is not an experimental study, the relationship could well indicate a reverse causal link.

E.g., patients with a higher likelihood of developing colorectal carcinoma may be predisposed to increasing their beef / milk consumption, which then shows in non-tumour tissues. In this light, the association might even demonstrate a protective effect against cancer (or at least its early symptoms).

One can easily find a biologically plausible explanation for this too. One of the early signs of cancer is loss of weight / appetite. It would make sense that people might instinctively turn to more 'umami/flavourful', low-carb/protein-high diets, to stimulate their appetite and combat the weight loss; particularly in terms of muscle mass.

This kind of explanation might also align with your observation on cancer rates in Europe vs South America. (assuming detection rates are similar in the first place).