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A comment on Simulation of tsunami from dinosaur-killing asteroid that brought 2.5 mile waves. Parent comment

Re:Simulation of tsunami from dinosaur-killing asteroid that... by cosmojg on Tuesday February 07, 2023 @03:58PM (#34699509)
Got any sources which discuss the heavy-tailed effects of drugs and how they're ignored by safety trials? I'd love to read more!
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Re:Simulation of tsunami from dinosaur-killing asteroid that... by nextos on Wednesday February 08, 2023 @03:46AM (#34705704)
I don't have references with me right now, but there are quite a few reputable studies that have found effects to be log-normal.

Log-normal is a quite nasty heavy-tailed distribution as it's easy to take it for normal if you have small sample sizes.

This has tricked the safety calculations of a few trials. I don't think it's too worrying or generalized, just some area to improve.

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