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A comment on Antidepressants help bacteria resist antibiotics. Parent comment

Re:Antidepressants help bacteria resist antibiotics by lr4444lr on Wednesday January 25, 2023 @11:29AM (#34520319)
That was exactly my first thought. We could definitely throw the SSRI efficacy into doubt though by sampling CS fluid or something for actual serotonin content in cohorts who are subjectively feeling improved by SSRIs.
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Re:Antidepressants help bacteria resist antibiotics by andy_ppp on Wednesday January 25, 2023 @11:37AM (#34520444)
It would also explain why SSRIs take time to work - as I understand it the SSRI action is immediate and yet it takes weeks for people to notice the effects.
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Re:Antidepressants help bacteria resist antibiotics by kayodelycaon on Wednesday January 25, 2023 @11:40AM (#34520492)
SSRIs aren’t the only medication that requires weeks to work.
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Re:Antidepressants help bacteria resist antibiotics by NickM on Wednesday January 25, 2023 @02:23PM (#34522914)
SSRI efficacy is already in doubt, as roughly 80% of the beneficial effects are replicated by placebos; some research has suggested that the remaining difference is due to the side effects, which make SSRIs active placebos and mess with study blinding.

And, even if they are better than just an active placebo, the mechanism is probably not the effects on serotonin levels. (Discussed previously here: https://news.ycombinator.com/item?id=32160703)

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Re:Antidepressants help bacteria resist antibiotics by password11 on Wednesday January 25, 2023 @07:40PM (#34526310)
That would only throw into doubt SSRI efficacy for increasing serotonin levels. Not SSRI efficacy for treating depression.
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