Personally, it makes a lot of sense to me that the immune system is responsible for much more than viruses or bacteria. The need for a class of diseases related to an unhealthy one (autoimmune diseases) is proof IMO
This is a simplification of a well researched process which we understand and can read about. What the previous poster wrote was just speculation as far as I can tell, unless someone wants to post some reference about cleaning the brain and blood?
"The spleen plays very important roles in regard to red blood cells (erythrocytes) and the immune system. It removes old red blood cells and holds a reserve of blood, which can be valuable in case of hemorrhagic shock, and also recycles iron."
Side effects and downstream effects are common across almost all drugs.
It's not absurd or unfounded to hypothesize an explanation for the correlation researchers observed. It could be the case, it could be something else or it could be the case that the correlation means nothing.