Point is, unfortunately, Twitter's dying and its prognosis is poor. We can imagine it'll get better but the realistic strategy is to bail.
(My previous post lacked empathy, and I apologize for that. Some billionaire asshole spent a lot of money to break something that worked for a lot of people. That's not fair to them.)
- qoto.org: member of United Federation of Instances. Relatively inclusive (and has some interesting extensions running on the base Mastodon service), but not necessarily federated to all the instances mastodon.social is federated to because they don't have a strict "Nazis fuck off" policy.
- mastodon.lol: antifa / LGBTQ+ / hacker-friendly node. Strict "Nazis fuck off" policy.
- infosec.exchange: InfoSec-focused Mastodon node, but pretty open with a pretty regular policy.
I think the strategy I'd probably recommend for a new user is something like "Join at mastodon.social, follow some people, and lurk. If you see many people you like who live at a particular node, migrate to that node."
(And honestly, unless a defederation fight breaks out, 90% of nodes are pretty interchangeable with each other; you can follow anyone the node federates to so it doesn't matter over-much which node you're on unless you want some specific features or you want admins who have a particular attitude towards your bugbear-topics).
Also you don't have to fret about what instance you start off on. I started with one of the generic instances and then after a week of lurking I migrated my account to an instance that I wanted to join (which moves over all your followers/followings but not your posts)