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A comment on Amygdala connectivity predicts ketamine treatment response among patients (cont). Parent comment

Re:Amygdala connectivity predicts ketamine treatment respons... by curioussavage on Monday November 28, 2022 @12:24PM (#33776424)
Auvelity, a drug that combines dextromethorphan and bupropion (included to keep the dextromethorphan in the system longer) was just made available this quarter.
[ Parent | on HN ]
Re:Amygdala connectivity predicts ketamine treatment respons... by cmrdporcupine on Monday November 28, 2022 @07:01PM (#33781713)
I kind of .. DIY'd this combination myself for a bit.

It allows you to take a much lower dose of dextromethorphan and so have fewer undesirable side effects. It helped me cope with some chronic physical pain I was suffering with at the time (in addition to depression).

[ Parent | on HN ]
Re:Amygdala connectivity predicts ketamine treatment respons... by cmrdporcupine on Monday November 28, 2022 @07:07PM (#33781762)
"Although Axsome has not yet announced a price, it’s anticipated that it will be a relatively expensive product compared with generic SSRIs and SNRIs, which are very well-established on the MDD market. With a comparatively high expected price, Auvelity may see its use restricted by payers to second and later lines of therapy."

This is insane gouging, as you could literally make it yourself by getting a prescription for generic bupoprion and some store-bought cough medicine.

[ Parent | on HN ]