That paper you linked to had 26 participants.
[1] https://thesource.com/2018/11/21/fasting-for-72-hours-can-re...
My impression is that ketogenic diet alone is insufficient for lack of aggressive autophagy/mitophagy fasting triggers. But I'm just a lowly software dev, this shit is not at all my wheelhouse. It doesn't surprise me though that our cells need regular spring cleaning, my home certainly does. Apparently we evolved to opportunistically do that internal spring cleaning in times of scarcity...
Worth a listen:
Dementia patients will have bigger symptoms later in the day, peaking at dusk.
Yes sometimes it seems people are not aware that it can be organic, locally sourced, home made from whole ingredients, vegan, if it’s a pastry it’s still “unhealthy” (if it’s not occasional).
Intermittent fasting usually kicks you into ketosis. Ketosis is when your body runs out of glucose and it metabolizes fat in the liver to use for energy, including the brain, which starts getting 66% of its energy from fat. You're on HN so you probably already know that. In fact, ketosis mainly affects the brain's metabolism. It also changes the krebs cycle, and eventually it changes how your body processes ketones themselves, but the important switch is in your brain.
Nutritional ketosis is a form of "fed" ketosis, where you mainly don't eat glucose, and eat more fat, and your body enters a similar state as fasting, except you don't have to be hungry. Nutritional ketosis is also distinguished from "starvation ketosis" (like from fasting) by the quantity of ketone bodies in the serum.
Alzheimer's patients on a ketotic diet show improvement (https://pubmed.ncbi.nlm.nih.gov/33622392/)
Could a nutritional ketosis diet be preventative against Alzheimers?
I sometimes hear stories of friends who eat generally "healthy," and aren't overweight, shocked to learn they are pre-diabetic.
This is the limit of my knowledge, and I know this is an incomplete picture. From my limited view, this is why I strive to be in nutritional ketosis.