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Re:A gut-derived hormone suppresses sugar appetite/regulates... by bugfix-66 on Sunday November 13, 2022 @10:35AM (#33583958)
Many foods you used to like (e.g., sweets) will be nauseating.

Other foods remain delicious. For example, eggs and cheese and meat.

But basically, your interest in food will be drastically reduced, and you will eat just enough.

This is an important part of metformin's beneficial effect on lifespan and health.

Re:A gut-derived hormone suppresses sugar appetite/regulates... by TylerE on Sunday November 13, 2022 @11:17AM (#33584416)
Admittedly, I’m on a fairly low dose (500mg x 2), but I can still kill a bag of Haribo when the mood hits. It doesn’t , quite as often, but I’ve noticed no changes in flavor.
Re:A gut-derived hormone suppresses sugar appetite/regulates... by bugfix-66 on Sunday November 13, 2022 @11:42AM (#33584712)
Thanks for the anecdote. Biological variation, we're all different!
Re:A gut-derived hormone suppresses sugar appetite/regulates... by dwaite on Sunday November 13, 2022 @01:30PM (#33585858)
Can you point to any studies around this?

I've never heard of this effect (let alone experienced it).

I do know that Diabetes itself can reduce the efficiency of taste receptors, and metformin will sometimes cause people to have a metallic taste in their mouth (due to metformin in produced saliva)

Re:A gut-derived hormone suppresses sugar appetite/regulates... by bugfix-66 on Sunday November 13, 2022 @01:39PM (#33585977)
It's easy to find studies connecting metformin to weight loss and loss of appetite. I'll leave that to you.

Just use Google if you want anecdotal examples of changes in the response to food (changes in palatability and taste), for example:

https://forum.diabetes.org.uk/boards/threads/loss-of-appetit...

or

https://www.diabetes.co.uk/forum/threads/anyone-experience-l...

>Metformin changed the taste of food slowly during the time I took it. It finally got to the point where all vegetables tasted like burnt plastic. This meant that I didn't want to eat them.

And so on.