For sure you can. I had this workflow with manually added keybindings through many methods over the years: skhd, Hammerspoon, BetterTouchTool etc.

I just found that the functionality is useful enough to warrant an app that can dynamically assign these hotkeys based on the apps I use.

For example I change browsers often to test new additions. And because I have rcmd-B set to focus/launch/hide my current browser app, I can keep my muscle memory even after switching from Safari to Firefox. In rcmd I just press rcmd-ralt-B to reassign that hotkey, in previous workflows this involved editing a specific file, or opening a preferences window and finding the right setting to change.

The experimental window switching/opening using Right Option is also something very useful and really hard to replicate using default macOS tools.