Honestly I find the defaults plus uBlock Origin and Multi-Account Containers to be fine, no bearing required.

I must have a hundred things that I change on every install. At a bare minimum I'd be disabling pocket, prefetch, and search from the address bar for privacy reasons and then disabling service workers, webgl, and wasm for security reasons.

OTOH, Firefox funding depends almost entirely on Google so they are unlikely to do anything that upsets Google too much.