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A comment on Dextromethorphan-Bupropion in Major Depressive Disorder: Controlled Trial. Parent comment

Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by sallystarace on Wednesday September 28, 2022 @06:41PM (#33014158)
Dextromethorphan tolerance builds so rapidly. I have found the withdrawal to be hell after taking it legitimately for a cold longer than I realized. I have tried SSRIs and found that they also have a synergetic effect with Bupropion (good medicine). SSRIs also make me drowsy, but at least they can be sustainably taken daily for months.
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Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by mmastrac on Wednesday September 28, 2022 @07:47PM (#33014640)
I had good luck with a prescribed combo of modafinil + buproprion. No drowsiness, much higher motivation.
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Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by hungrigekatze on Wednesday September 28, 2022 @11:01PM (#33015841)
Does that lower the seizure threshold at all? (I've had docs get on my case about bupropion + mild other medication that can in theory impact the seizure threshold) But I'd be interested - potentially - in trying this combo as things are pretty cobwebby in the brain department lately.
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Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by epicureanideal on Wednesday September 28, 2022 @07:53PM (#33014680)
Modafinil alone didn’t have that effect?
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Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by mmastrac on Wednesday September 28, 2022 @08:27PM (#33014910)
It helped, but the combo beat both depression and lack of motivation much more effectively.
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Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by gremlinsinc on Thursday September 29, 2022 @04:56AM (#33017996)
Sounds like me, except Vyvanse instead of Modafinol. Bupropion was the magic key. I thought my Vyvanse just wasn't working anymore.

Turns out I was just super depressed. Since switching meds I've lost a lot of weight because I don't have food cravings as much.

The way I think of it... Vyvanse keeps me focused when I get to work, but without Bupropion just getting out bed sometimes seems daunting. One gets me to start my day, the other keeps me focused when I do.

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Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by floatinglotus on Wednesday September 28, 2022 @08:07PM (#33014770)
What dosage of modafinil?
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Re:Dextromethorphan-Bupropion in Major Depressive Disorder: ... by mmastrac on Wednesday September 28, 2022 @08:26PM (#33014903)
Pretty low, but I tend to find lower doses than average to be effective.
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