This would result in half the planet being frustrated all the time and the other half never getting their mail.
If your goal is to secretly destroy email this is the way.
Yup. I do want people to be able to contact me regarding my homepage. It's only a niche page on a niche subject, so only a handful of people has written in, but it was nice hearing from them and some of them did make quite a few valuable contributions.
Some minimal obfuscation seems to be enough to keep mail harvesters away, and beyond that those mails go through the same spam filter as all my other mail traffic. Putting up a contact form would definitively be more of a hassle than just a simple mailto:-link, and then I would additionally have to start worrying about how to keep the bots away from that contact form.
What I'm describing is a situation where users themselves have to proactively subscribe to a connection using some sort of out-of-band mechanism. For example, if a website wanted to send you emails, they could produce some sort of "connection ticket" that you can give to your email client in order to subscribe to them.