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A comment on Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy. Parent comment

Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by JumpCrisscross on Wednesday August 31, 2022 @12:42PM (#32664816)
> wouldn't call protein breakdown in the muscle "wasting" without additional effects

Fair enough, given it's voluntary [1]. It's biologically identical to wasting, however.

[1] https://en.wikipedia.org/wiki/Wasting

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by wang_li on Wednesday August 31, 2022 @01:45PM (#32665760)
There's some evidence that exercising during the fast helps minimize the loss of muscle.
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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by JumpCrisscross on Wednesday August 31, 2022 @02:33PM (#32666412)
> some evidence that exercising during the fast helps minimize the loss of muscle

The original point was autophagy reactivates mTOR. This isn’t a linear system. It could be that a 20-hour fast downregulates mTOR more than a 30-hour fast. (We know it works at 72 hours.)

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