Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy

Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by nils-m-holm on Wednesday August 31, 2022 @10:10AM (#32662246)

> One of the ways to inhibit mTOR for free to simply stop consuming nutrients for extended periods of time.

What is an extended period of time in this context? I happen to consume all my meals within seven hours every day and only drink water in between. Would that help?

(Not doing this for health reasons, it is just a habit.)

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by nik_s on Wednesday August 31, 2022 @10:56AM (#32662865)

This [1] study was pretty thorough on different fasting lengths. They tested 1422 patients for fasting lengths between 4 and 21 days, with a maximum calorie consumption of 200-250kcal and a moderate-intensity lifestyle program.

It concludes that all fasting lengths are beneficial, and are likely going to result in a) reduction in weight and waist circumference, b) beneficial effects on blood lipids, regulation of sugar and other blood-related parameters, including lower blood sugars and higher ketone body levels, c) an increase in physical and emotional well-being and absence of hunger, d) a high probability of decrease of pre-existing health-complaints, e) very limited chance of side-effects.

[1] https://journals.plos.org/plosone/article?id=10.1371/journal...

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by orangepurple on Wednesday August 31, 2022 @11:01AM (#32662930)

To build on this post it is further beneficial to understand the importance of the interaction between clock genes and nutrient intake timing for optimal results

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by rngname22 on Wednesday August 31, 2022 @10:40AM (#32662623)

https://podcastnotes.org/high-intensity-health/attia-7/

Around day 3 or day 4 of a water-only fast or (the potentially easier but still effective option of) of a fasting-mimicking diet fast.

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by forgotmypw17 on Wednesday August 31, 2022 @10:34AM (#32662537)

A good measure is whether or not you feel that empty, churning feeling in your stomach. Another good measure is if you're into the idea of eating something like plain cabbage or oats.

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by jtbayly on Wednesday August 31, 2022 @11:01AM (#32662937)

I feel that after a few hours of not eating. Is feeling it or not feeling it the sign that I've reached the necessary effect?

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by funnym0nk3y on Wednesday August 31, 2022 @08:23PM (#32670127)

I have no personal experience with this, so I must have read I somewhere. Usually in the first hours your get hungry, which eases off after some time. After that, you can until you are hungry again.

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by forgotmypw17 on Thursday September 01, 2022 @12:55AM (#32672167)

I think it is bare minimum for good clean digestion. As far as ALL the benefits of fasting... I think it is a good start.

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Re:Rapamycin, drug used in cancer therapy, emerges as powerf... by simonebrunozzi on Wednesday August 31, 2022 @03:49PM (#32667396)

Not an expert by any means, but based on some sparse reading I'd guess it's in the "few days" range, not a few hours.

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